FTH1 and familial pancreatic carcinoma: As shown in Fig. 4c, the cell cycle analysis results indicated that FTH1 may be crucial for cell cycle regulation in pancreatic cancer cells: with FTH1 expression rescue, the percentages of cells in the G0/G1 phase increased from 45.2% to 54.1% in SUIT-2/shFTH1#1 cells and from 44.6% to 52.0% in SUIT-2/shFTH1#4 cells, followed by a substantial reduction in the percentage of cells in the G2/M phase (Supplementary Fig. 1c, d).