We found that the expression of FTH1 and FTL significantly decreased with DFX treatment (Fig. 8b) and that the PYCR1/PRODH expression ratio decreased with 20 μM DFX treatment (Fig. 8d, c), suggesting that a high dose of DFX treatment inhibits the crosstalk between FTH1 and PYCR1 and leads to the suppression of pancreatic cancer cell viability. This evidence concerns the gene PYCR1 and familial pancreatic carcinoma.