To further explore how FTH1 is linked to the reprogramming of proline metabolism in pancreatic cancer cells, we measured the protein expression of proline metabolism-associated molecules, PYCR1 and PRODH, in control and shFTH1-infected SUIT-2 cells through Western blotting (Fig. 4d, left panel). The gene discussed is PRODH; the disease is familial pancreatic carcinoma.