On the basis of the results of Xu et al.24, we regarded miR-1253, miR-6081, miR-3150a-3p, miR-2355-5p, and miR-5000-3p as the five candidate miRNAs potentially targeting PYCR1; our study revealed a nuanced role for miR-2355-5p and miR-5000-3p in the context of pancreatic cancer. This evidence concerns the gene PYCR1 and pancreatic neoplasm.