PRODH and familial pancreatic carcinoma: We found that the expression of FTH1 and FTL significantly decreased with DFX treatment (Fig. 8b) and that the PYCR1/PRODH expression ratio decreased with 20 μM DFX treatment (Fig. 8d, c), suggesting that a high dose of DFX treatment inhibits the crosstalk between FTH1 and PYCR1 and leads to the suppression of pancreatic cancer cell viability.