We also observed that FTH1 and PYCR1 overexpression in SUIT-2/shFTH1#4 cells considerably rescued the inhibitory effects of 10 μM and 20 μM DFX after 72 h, suggesting that FTH1/PYCR1 expression is key for the anti–pancreatic cancer activity of DFX (Fig. 8a). Here, PYCR1 is linked to familial pancreatic carcinoma.