We first investigated whether Thal or Len could modulate the expression of ACE2 receptor in association with ΔNp63α degradation in human cells, such as HaCaT keratinocytes, A431 epidermoid cells, and A549 lung carcinoma cells, which express both ΔNp63α and ACE2 proteins. The gene discussed is ACE2; the disease is lung carcinoma.