ACE2 and infection: First, our data envisage new roles of p63 on the regulation of cell protein expression and support the general concept that Thal may efficiently modify the expression of genes through p63 regulation, among which is ACE2. Second, they support a protective role for Thal against SARS-CoV-2 viral infection and explain the molecular details of how this compound exerts its functions, potentially making it a valuable option in the management of SARS-CoV-2 or other ACE2-dependent infections.