Binding of the adaptors was confirmed by BIAcore analyses on chips coated with cognate antigens with dissociation constants in the low nanomolar range (Fig. 1H, I) and by staining MOLM14-CD117highGFP+Luc+ AML cells, positive for CD33 and CD117, exhibiting semi-saturation in the low nanomolar range (Fig. 1J). This evidence concerns the gene CD33 and acute myeloid leukemia.