Cortisone reductase deficiency, caused by inactivating mutations in the enzyme Glucose 1-dehydrogenase/hexose-6-phosphate dehydrogenase (H6PD), mimics of PCOS and manifests as hyperandrogenism that cannot be explained by standard tests (Qin and Rosenfield 2011)68. This evidence concerns the gene H6PD and polycystic ovary syndrome.