First, we did not assess and control for further potentially confounding factors of IMT and diameter, such as familial hypercholesterolemia,71 increased concentrations of serum c-reactive protein,72 serum uric acid,73 plasma total homocysteine,74 and cholesterol level,75 as well as pubertal maturation,76 maternal obesity,77 or birth-related issues.78,79 Second, the trainability of VO2peak, the main parameter for determining CRF, is genetically determined up to 50%80 and may interfere with the interpretation of arterial adaptation caused by regular exercise. Here, CRP is linked to familial hypercholesterolemia.