Surprisingly, both the protein and mRNA levels of ALKBH5 were upregulated in HFD-induced cardiac hypertrophy (Fig. 1F, G), while Fat mass and obesity-associated protein (FTO), the first reported m6A demethylase in eukaryotic cells, was also upregulated but not as high as ALKBH5 (Fig. S1). This evidence concerns the gene FTO and cardiac hypertrophy.