We observed that the transcriptional profile of ALKBH5 increased in left ventricle tissue of patients with ischemic cardiomyopathy (ICM) (P = 0.000242) or dilated cardiopathy (DCM) (P = 0.019) compared with donors with nonfailing (Control) myocardium (Fig. 1A). This evidence concerns the gene ALKBH5 and familial dilated cardiomyopathy.