ALKBH5 and cardiac hypertrophy: Surprisingly, both the protein and mRNA levels of ALKBH5 were upregulated in HFD-induced cardiac hypertrophy (Fig. 1F, G), while Fat mass and obesity-associated protein (FTO), the first reported m6A demethylase in eukaryotic cells, was also upregulated but not as high as ALKBH5 (Fig. S1).