More common in children, these rearrangements were not identified in our adult cohort (Supplementary Data 1), and gene sets associated with these rearrangements, including TCF3-ZNF384 B-ALL, ZNF384-rearranged B-ALL or MPAL, BCL11B-expressing CD34+ cells, and BCL11B-expressing T-ALL cells were not significantly enriched in MPAL leukemic blasts (Supplementary Data 6; Fig. 2a)5,25–27. This evidence concerns the gene TCF3 and acute lymphoblastic leukemia.