Over-expression of total53 and exon 10-containing (4-repeat)9 MAPT mRNA in subjects homozygous for the PSP risk-associated MAPT H1 haplotype is modest and insufficient alone to cause PSP, suggesting that other factors in addition to Tau expression levels contribute to the initiation of pathogenesis. Here, MAPT is linked to supranuclear palsy, progressive, 1.