Together the data in Figs. 3 and 4 show that human 0N/4R-Tau in the zebrafish brain loses solubility and becomes hyperphosphorylated, mislocalized, misfolded, truncated, and oligomerized, replicating many features of human tauopathies including PSP. The gene discussed is MAPT; the disease is supranuclear palsy, progressive, 1.