Our findings that (+)JQ1-mediated mitigation of microglial synaptic phagocytosis is phylogenetically conserved between Tau zebrafish and a rat primary culture model, and that Brd4 is expressed in human microglia in PSP, are together encouraging that Brd4 may regulate microglial synaptic pruning in PSP in a pharmacologically-targetable way. Here, BRD4 is linked to supranuclear palsy, progressive, 1.