The scope of this study is to test the hypothesis that hNGFp can exert a rescue effect on the bystander degeneration of cones in a mouse model of RP by virtue of its demonstrated ability to direct microglial cells toward a homeostatic configuration and to exert a neuroprotective action on CNS neurons even when (as is the case for retinal cones) they do not express the NGF receptor TrkA. Here, NTRK1 is linked to retinitis pigmentosa 1.