In addition, BGJ398 and the overexpression of Ick, Mak, and Ccrk could rescue ciliary defects because of the deficiency of Dync2li1, a ciliopathy gene encoding a subunit of cytoplasmic dynein 2 (80), which supports the idea that the Ccrk-Mak/Ick axis engages in the turnaround process and subsequent retrograde IFT. The gene discussed is MAK; the disease is ciliopathy.