MAPT and Alzheimer disease: found several associations between AD-risk genes and both Aβ (positive: CNTNAP2, MADD, and PTK2B; negative: INPP5D, HLA-DRB1, and WWOX) and tau (positive: AGRN and PLD3; negative: ADAMTS4, EPHA1, CD2AP, and PICALM) spatial maps, which were replicated across two cohorts and, in the case of Aβ, two sets of PET tracers.