This indicates that these two components participate in the development of post-MI heart failure (HF).The study by Dickhout et al. observed that 3-NT could colocalize with GRP78 within early atherosclerotic lesions in the walls of arteries, suggesting that nitrosative/oxidative stress and ER stress also contribute to other diseases like coronary artery disease (CAD) [35]. This evidence concerns the gene HSPA5 and heart failure.