In addition to the accumulation of iron-dependent free radicals, it has been demonstrated that the peroxidation of polyunsaturated fatty acids (PUFAs), a process mediated by lipoxygenase (LO) enzymes within the ferroptotic pathway, underlies α-synuclein protein aggregation, which is a key pathological hallmark of PD [12, 13]. Here, SNCA is linked to Parkinson disease.