Apart from eczema [14], earlier studies have demonstrated that CRNN is downregulated in various types of cancers, including esophageal squamous cell carcinoma, oral squamous cell carcinoma, cervical squamous cell carcinoma, head and neck squamous cell carcinoma, and thyroid cancer [11, 13, 15, 17, 19, 22–25]. This evidence concerns the gene CRNN and oral cavity squamous cell carcinoma.