Significant differences (at the nominal 5% level) are seen for six disease traits (larger female effects for age-related macular degeneration and hypertension; larger male effects for asthma, cardiovascular disease, coronary artery disease and venous thromboembolic disease), and nine quantitative traits (larger female effects for apolipoprotein B, creatinine-based estimated glomerular filtration rate, HDL cholesterol, remnant cholesterol, resting heart rate, sphingomyelins, total cholesterol and total triglycerides; larger male effect for calcium). This evidence concerns the gene APOB and asthma.