Like the LRIT3 KOs, nyctalopin KOs retain TRPM1 in ON BC cell bodies (Agosto et al. 2018, Hasan et al. 2019, Neuille et al. 2015, Pearring et al. 2011), suggesting that both molecules are required for the appropriate localization of TRPM1 channels to ON BC dendritic tips. The gene discussed is TRPM1; the disease is breast cancer.