HLA-C and cardiovascular disorder: We then explored the presence of sex-specific and HLA-C*06:02 subgroup–specific differences in MR effects given the higher prevalence of cardiovascular disease in females (vs males) with psoriasis55,56 and in those who have no copies HLA-C*06:02 allele (vs participants carrying 1 or 2 copies of the HLA-C*06:02 allele).