Found that cannabidiol activation of vagal afferent neurons requires TRPA1, suggesting a novel pathway for the endocannabinoid system in modulating satiety. The study suggests that CBD's activation of vagal afferent neurons could influence appetite regulation and energy balance through its effects on the endocannabinoid system. By modulating these pathways, CBD may play a role in managing obesity and related metabolic disorders. Here, TRPA1 is linked to obesity due to melanocortin 4 receptor deficiency.