The quadruple knockout ∆ist/∆gra16/∆gra24/∆gra28 also phenocopied Δmyr1 infection effect on host cell survival upon IFNγ treatment in combination with Compound 1, showing a nearly 60% infected cell death rate accumulated over 60 h of continuous time-lapse observation (Fig. S7C). The gene discussed is IFNG; the disease is infection.