Similar to results observed with hACE2-HEK293 cells, infection with Omicron BA.2 or Omicron BA.4/BA.5 SARS-CoV-2 pseudoviral particles led to increased activation of the EGFR and ERK1/2 pathways in hACE2-A549 cells (Fig. 3A). The gene discussed is MAPK3; the disease is infection.