STING1 and vascular disorder: For example, initially described as a type I interferonopathy (Liu et al., 2014), recent studies in STING-associated vasculopathy with onset in infancy (SAVI) mouse models showed that SAVI is largely independent of type I IFNs (Luksch et al., 2019; Stinson et al., 2022; Warner et al., 2017; Frémond et al., 2021).