STING1 and cancer: The uncertainty likely results from studies using different cell types (primary cells vs cancer cell lines); species (human vs mouse); STING1 agonists (cGAMP, which requires cell permeabilization by detergents or lipid transfection, vs diABZi, DMXAA that can directly cross the membrane; Larkin et al., 2017; Cerboni et al., 2017; Gulen et al., 2017; Kabelitz et al., 2022; Wu et al., 2019).