To the best of our knowledge, this study is the first to focus only on cases of polycystic kidneys without a positive family history of polycystic kidneys and to identify the subclinical rate of IFT140. We compared the proportion of monoallelic loss-of-function IFT140 variants between the general ADPKD cohorts and cases without a positive family history of polycystic kidneys (Table 5). This evidence concerns the gene IFT140 and polycystic kidney disease.