APOL1 and glomerular disorder: An estimated 30% of eligible Americans remain unvaccinated or have not been fully vaccinated against SARS-CoV-2.1, 2, 3 Recent case reports of new onset glomerular disease in temporal association with SARS-CoV-2 vaccination brought renewed concerns about the vaccine’s safety in predisposed populations with established immune-mediated glomerular disease or a genetic susceptibility.4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15 Individuals with APOL1 HRG (G1G1, G1G2, and G2G2) are one such population.