The absence of proteinuria or increase in serum creatinine following SARS-CoV-2 vaccine in 105 community dwelling African Americans in our study, irrespective of their APOL1 genotype, suggests that SARS-CoV-2 vaccine is unlikely to be a common second hit trigger of APOL1-mediated kidney disease like interferon gamma and viral infections. The gene discussed is IFNG; the disease is kidney disorder.