APOL1 and hypertensive disorder: Although social and structural determinants of health, including racism, poverty, discrimination, and lack of access to health care contribute to racial inequities in kidney health,2 2 protein-coding variants of the gene apolipoprotein L1 (APOL1), G1 and G2, found exclusively in individuals of recent West African ancestry, account for much of the excess risk of FSGS and HTN-ESKD in African Americans.3