TARDBP and amyotrophic lateral sclerosis: Detecting and promoting the removal of the misfolded protein in amyotrophic lateral sclerosis patient3-5 is mediated by the heat shock protein B8 (HSPB8), which works with the co-chaperone BAG3, forming the HSPB8–BAG3–HSP70 complex.6 More specifically, HSPB8 inhibits TDP-43 and its C-terminal fragment of 25 kDa (TDP-25) accumulation.