The first aim of our current study was to investigate the frequency of WMHs in patients with dementia with Lewy bodies in comparison to groups of patients with other dementias, mild cognitive impairment and cognitively unimpaired participants and to elucidate if WMHs are associated with MTA, Aβ and phosphorylated tau (p-tau) biomarkers of Alzheimer’s disease and cognitive performance. Here, MAPT is linked to Cognitive impairment.