The main AD-related plasma biomarkers are Aβ42 or Aβ40 and the phosphorylated tau marker (p-tau) at threonine 181, 217, 231.10-12 There are also dementia-non-specific plasma analytes that are related to neurodegeneration and neuroinflammation such as the neurofilament light (NfL) associated with axonal integrity,13 and glial fibrillary acidic protein (GFAP) which is an indicator of astroglial activation and astrocytosis. This evidence concerns the gene MAPT and Alzheimer disease.