α-Tph and α-T3 tend to enhance the production of Aβ (via β-secretase and γ-secretase production) and decrease the degradation of Aβ, thereby facilitating the accumulation of plaques.50 When vitamin E alone had the potential to increase p-Akt, lower oxidative stress via decreasing ROS production that occurs as a result of insulin resistance, and reduce AD markers like GSK3β and TAU. This evidence concerns the gene AKT1 and Alzheimer disease.