Proteomic studies have uncovered SMOC-1 to be highly enriched in a subpopulation of amyloid plaques, in AD patients and to be elevated in asymptomatic AD cortex.6 Recently, SMOC-1 was shown to be elevated in cerebrospinal fluid from AD patients.7 Although it remains unknown why SMOC-1 co-localizes with only some amyloid plaques, it is hypothesized that SMOC-1 may interact with amyloid-beta (Aβ) species that have been subjected to post-translational modifications.6 More comprehensive research is required to examine the mechanistic role of SMOC-1 in AD. Here, SMOC1 is linked to Alzheimer disease.