TNF and sleep disorder: Sleep disorders can be associated with some biochemical variations like: chronic activation of stress hormones,6,7 abnormalities in appetite-regulating hormones,8,9 increased levels of inflammatory cytokines such as interlukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), IP-10 (an interferon-inducible protein-10 linked to inflammation), and high-sensitivity C-reactive protein (hsCRP),10 and changes in gut microbiota.11