MiRNAs are not only involved in the epigenetic regulation of PC development, but also act as regulatory factors for epithelial-mesenchymal transition (EMT).Gurbuz et al. (2022) discovered that downregulated miR-193b can prevent the proliferation, migration, invasion, and EMT of PC cells by inhibiting the eEF2K/MAPK-ERK axis. Here, EEF2K is linked to pachyonychia congenita.