A study revealed that (Wood et al., 2022) the occurrence of PC is accompanied by a large number of gene mutations, with the main driving genes include KRAS, TP53, SMAD4, and CDKN2A. In addition, abnormal epigenetic modifications also promote the occurrence and development of PC by regulating chromatin structure and gene expression. This evidence concerns the gene CDKN2A and pachyonychia congenita.