The mechanism underlying its induction of hepatitis may be associated with the activation of noncanonical nuclear factor-κB (NF-κB), signal transducer and activator of transcription 3 (Stat3), and the mammalian family of mitogen-activated protein kinases (MAPKs) (Pellicano et al., 2008; Cao et al., 2020). The gene discussed is STAT3; the disease is hepatitis A virus infection.