For instance, pheochromocytomas are specific for chromogranin A and CD56, while an adrenocortical origin would be suggested by positive for calretinin, MART-1, and inhibin A. Synaptophysin levels can be elevated in both pheochromocytomas and adrenal cortical tumors [14]. The gene discussed is CHGA; the disease is hereditary pheochromocytoma-paraganglioma.