A2AR, A2BR, and A3R were mostly involved in cancer development (Shi et al., 2019; Willingham et al., 2018; Cekic et al., 2012; Vecchio et al., 2016; Harvey et al., 2020), inflammation (Mediero et al., 2015; Barletta et al., 2012; D'Antongiovanni et al., 2020), and cardiac disease (Lu et al., 2008), among others. This evidence concerns the gene ADORA2A and cancer.