TDP-43, FUS/TLS, TATA-box binding protein associated factor 15 (TAF15), Ewing’s sarcoma RBP 1 (EWSR1), and HNRNPA1, all proteins that form pathological aggregates in ALS, are recruited in paraspeckles (Naganuma et al., 2012). The gene discussed is HNRNPA1; the disease is amyotrophic lateral sclerosis.