TARDBP and amyotrophic lateral sclerosis: For instance, miR-27b-3p and miR-181c-5p, two miRNAs that are reduced in ALS, downregulate TDP-43 expression as a part of a negative feedback loop dependent on TDP-43 nuclear localization (Campos-Melo et al., 2013; Hawley et al., 2020).