It has been described that the bromodomain and extraterminal domain (BET) family of proteins that includes four conserved mammalian members of bromodomain-containing proteins (BRDs): BRD2, BRD3, BRD4, and BRDT, regulate the C9orf72 locus in ALS and that BRD inhibitors could have therapeutic potential for this disease (Zeier et al., 2015). This evidence concerns the gene C9orf72 and amyotrophic lateral sclerosis.