TARDBP and amyotrophic lateral sclerosis: Liquid-to-solid phase transition in pathological conditions has been observed for several RBPs, including the ALS-related proteins TDP-43 (encoded by TARDBP) and FUS/TLS (encoded by FUS) (Carey and Guo, 2022), in a process that can be accelerated by ALS-associated mutations (Patel et al., 2015).