In fact, it has been observed that in the early phase of ALS, NEAT1_2, one of the two isoforms of NEAT1, is upregulated, binds to TDP-43 and FUS/TLS, and induces paraspeckle formation in motor neurons, modulating the levels and functions of these ALS-associated RBPs (Nishimoto et al., 2013). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.