The expression of HDAC4, an epigenetic factor responsive to stress, is significantly increased in the skeletal muscle of ALS patients and mice (SOD1-G93A) with denervation (Pigna et al., 2019) and is present in neuronal cytoplasmic inclusions (Federspiel et al., 2019). This evidence concerns the gene HDAC4 and amyotrophic lateral sclerosis.