C9orf72 and amyotrophic lateral sclerosis: Specifically, in primary cortical neurons from a C9orf72 ALS/FTD transgenic mouse model (C9BAC), treatment with PFI-1 and JQ1, both BRD inhibitors, enhanced the expression of the human mutant C9orf72 gene, increased the accumulation of nuclear RNA foci, and reduced poly (GP)-DPR inclusions, with reduced hippocampal-dependent cognitive impairments (Zeier et al., 2015).