In addition, a connection between anti-TNF treatment and IL-10 production has been proposed in multiple IMIDs [8]: patients with juvenile idiopathic arthritis [9], psoriasis [10], RA [11], or Crohn’s disease [12] were shown to have higher serum or cellular levels of IL-10 after treatment with anti-TNF. Here, IL10 is linked to juvenile idiopathic arthritis.