There was evidence for association at genome-wide significance (P < 5.0 × 10-8) for a single, novel risk locus, CCDC91. The lead signal was rs7316831, a common intronic variant within CCDC91 (allele frequency for A allele = 0.40; P = 4.35 × 10-9; OR for periodontal disease = 0.96). Here, CCDC91 is linked to periodontal disorder.