TNF and psoriasis: Similarly, glycoprotein acetyls, a systemic inflammatory marker associated with circulating leucocytes, TNF and IL-6, is also highly predictive of CVD, in both PsA and psoriasis.41,45 Further differences in the metabolome have also been identified in studies comparing people with psoriasis to those with PsA, with levels of inflammatory lipid mediators, especially leukotriene B4 and glycoursodeoxycholic acid, predictive of PsA progression.46 Both metabolites are associated with the development of CVD.47, –49