ALDH2 and amyotrophic lateral sclerosis: Hs-CRP was also found to have significant indirect effects on the relationship between ALDH2 rs671 (A) allele and ECAS total score (Indirect effect = −3.408, 95% CI = −7.637−−0.468) or ALS-specific score (Indirect effect = −3.016, 95% CI = −6.657−−0.602) despite the absence of total effects from ALDH2 rs671 (A) allele on the respective scores (Table 3).