IL1B and amyotrophic lateral sclerosis: For instance, the UNC13A rs12608932 polymorphism has been linked to an increased risk for both ALS and FTD (Vidal-Taboada et al., 2015; Tan et al., 2020) and interleukin 1 beta (IL-1β) rs1071676 polymorphism is involved in inflammation (Ravnik-Glavac et al., 2022).