Activation of NLR family apoptosis inhibitory protein (NAIP)-NLRC4 inflammasome is generally centered on mounting an immune response against gram-negative bacteria, such as Salmonella Typhimurium, but together with that, recent findings also show the role of this inflammasome in autoinflammatory diseases (82) as well as in cancers such as glioma and breast cancer (83). Here, NAIP is linked to central nervous system cancer.