Also, regarding PGE2, a recent study indicates the relationship between AIM2 upregulation and activation of the TNFα-NF-κB signaling by showing upregulated AIM2-mediated IL-1β secretion and activation of STAT1/NF-κB-related pathway in oral squamous cell carcinoma cells (170). Here, NFKB1 is linked to oral cavity squamous cell carcinoma.