PGE2 has been shown to induce Y box-binding protein 1 expression via activation of EP1-proto-oncogene tyrosine-protein kinase Src-epidermal growth factor receptor (EGFR)-p44/42 MAPK-mTOR pathway which increases the invasive ability of hepatocellular carcinoma cells (200). Here, EGFR is linked to hepatocellular carcinoma.