It has also been demonstrated in both bone-marrow-derived macrophages and phorbol myristate acetate-differentiated human monocytic leukemia cells that LXA4 can inhibit NLRP3 inflammasome formation by suppressing oxidative stress at the upstream of NLRP3 activation (through dropping NADPH oxidase activation, ROS generation, and mitochondrial dysfunction as well as modulating Nrf2 activity) (104). The gene discussed is NLRP3; the disease is monocytic leukemia.