AIM2 and Sepsis: Regarding the potential influence of reactive aldehydes on AIM2 activity, the study in mouse models of acute lung injury and sepsis revealed that the use of 4-HNE or increasing endogenous 4-HNE levels by inhibiting glutathione peroxidase 4 activity, independently of Nrf2 and NF-κB signaling, was able to reduce the activation of the NLRP3 inflammasome together with no effect on neither the NLRC4 nor AIM2 (121).