Besides, studies on peripheral blood mononuclear cells from patients with chronic obstructive pulmonary disease (PBMC) showed that the AIM2 inflammasome-dependent release of IL-1α was not related to the release of eicosanoids, as it did not show an increase in PGE2 levels in the case of AIM2 activation (162). Here, AIM2 is linked to chronic obstructive pulmonary disease.