On the other hand, RT can negatively modulate tumor immunity: 1) The reduction of lymphocytes and NK cells following RT leads to immunosuppression (22); 2) RT-induced activation of TGF-β promotes the proliferation of myeloid-derived suppressor cells (MDSCs) and M2 macrophages, creating an immunosuppressive tumor microenvironment (23). The gene discussed is TGFB1; the disease is neoplasm.