We then checked the 7 genes with the highest gene-disease association score (which is a quantification of the association between a gene and a disease taking into account the number and type of sources and the number of publications supporting the association) regarding Down syndrome in the DisGeNET database, and found the gene RCAN1 which relates to epigenetics was among our top genes mapped from methylation. The gene discussed is RCAN1; the disease is Down syndrome.