FNDC5 and metabolic disease: These clusters primarily focus on keywords related to metabolic diseases, such as “irisin,” “neurodegeneration,” “metabolic syndrome,” “mitochondrial dysfunction,” “human,” “cardiometabolic diseases,” “atrophy,” “metabolic reprogramming,” “adaptation,” “alcohol consumption,” and “animal models.” Figure 6B highlights the top 11 references with the most intense citation bursts, indicating emerging trends or growing interests in the field.