Brain magnetic resonance imaging (MRI) is mandatory or highly recommended to detect causative anatomic anomalies and rule out neoplastic lesions in many pediatric endocrinological conditions, such as central precocious puberty (CPP) (1) and growth hormone deficiency (GHD) (2) or other causes of short stature (OCSS) in which recombinant human growth hormone (rhGH) is prescribed such as Noonan syndrome (3). This evidence concerns the gene GH1 and central precocious puberty.