In this context, a recent study has documented that central pharmacological activation of FFAR1 in diet-induced obese mice decreased body weight and increased energy expenditure, while virogenetic knockdown of FFAR1 in ARC POMC neurons of obese mice evoked hyperphagia and body weight gain, as well as the development of hepatic insulin resistance and steatosis (70). The gene discussed is FFAR1; the disease is Insulin resistance.