The interaction between AGEs and RAGE activates multiple signaling pathways that critical for tumor growth, angiogenesis, and invasion, such as the PI3K/AKT/mTOR, MAPK, MMPs, vascular endothelial growth factor (VEGF), NF-κB, JAK/STAT, and p53 (127). Here, NFKB1 is linked to neoplasm.