RA was found to be a protective factor for Memory B cell %lymphocyte (B cell group) (OR, 0.861; 95% CI, 0.795–0.933; P < 0.001; PFDR = 0.050), CD4+ CD8dim T cell %lymphocyte (TBNK group) (OR, 0.802; 95% CI, 0.711–0.904; P < 0.001; PFDR = 0.043), CD4+ CD8dim T cell %leukocyte (TBNK group) (OR, 0.814; 95% CI, 0.726–0.913; P < 0.001; PFDR = 0.046), CD24 on IgD+ CD24+ B cell (B cell group) (OR, 0.857; 95% CI, 0.793–0.927; P < 0.001; PFDR = 0.038), and CD24 on unswitched memory B cell (B cell group) (OR, 0.867; 95% CI, 0.797–0.942; P < 0.001; PFDR = 0.050) (Supplementary Figure S8). The gene discussed is CD4; the disease is rheumatoid arthritis.