Mice implanted with blank PLA nanofiber membrane (PLA-NF) or MOF-loaded nanofiber membrane (MOF-NF) exhibited significant tumor growth, while mice implanted with cisplatin-loaded MOF (D@MOF-NF) or MCM4 siRNA-loaded membrane group (G@NF) showed a noticeable reduction in tumor size. The gene discussed is MCM4; the disease is neoplasm.