A prognostic signature associated with cuproptosis (Cu‐PS), comprising MAGE family member A6, cytochrome P450, family 26, subfamily b, polypeptide 1, complement C7, erythropoietin, and hexokinase 2, has been identified and analyzed, revealing a significant positive correlation with tumor node metastasis classification, drug sensitivity, tumor mutation load, and response to immunotherapy in HCC. This evidence concerns the gene EPO and neoplasm.