Copper overload promotes oxidative stress and cellular autophagy, with oxidative stress activating the NFE2 like bZIP transcription factor 2/peroxisome proliferator activated receptor gamma (NRF2/PPARγ) pathway and autophagy mitigating copper‐induced lipid deposition, thus offering protection against copper‐induced NAFLD.158, 159. The gene discussed is NFE2L2; the disease is metabolic dysfunction-associated steatotic liver disease.