Stem cells not only have multidirectional differentiation potential to promote liver regeneration but have influences on liver injury resistance, immunosuppression, myofibroblast suppression, ECM degradation and remodeling, as well as reducing liver fibrosis through secreting different cytokines (interleukin‐4, 6, 10), growth factors (hepatocyte growth factor, heparin binding endothelial growth factor, connective tissue growth factor), matrix metalloproteinases (MMP‐2, 9, 13), etc.105Stem cell therapy is considered an effective alternative therapy for liver diseases. The gene discussed is MMP2; the disease is Hepatic fibrosis.